I am quite happy with the fact that this solution has no tracks since if i try to add any it just makes it worse.
I converged on this layout pretty quickly in about 4 hours but after that i could barely make improvements after another 5 hours of searching all i could do is shave 2 area off.
The only gripe i have is that there is no glyph reuse each bond uses a different glyph and i think better solutions will have some glyph reuse but besides that i think the area and cycles part are quite decent.